Publications.
Gestion de la mucite orale et gastro-intestinale induite par les thérapies ciblées
Dans cet article, nous traiterons, à partir du référentiel ESMO 2015 (1), des lésions de la muqueuse buccale et du tractus gastro-intestinal liées à l'administration de thérapies ciblées.
PUBLIÉ LE : 06 novembre 2017
PARU DANS : La Lettre du Pneumologue / N° 5 / oct. 2017
Gestion de la mucite orale et gastro-intestinale induite par les thérapies ciblées
Dans cet article, nous traiterons, à partir du référentiel ESMO 2015, des lésions de la muqueuse buccale et du tractus gastro-intestinal liées à l'administration de thérapies ciblées.
PUBLIÉ LE : 28 novembre 2016
PARU DANS : La Lettre du Cancérologue / N° 10 / nov. 2016
Modalités de prise en charge du traitement par afatinib
L'afatinib est un ITK irréversible administré par voie orale de la famille ErbB. Il cible de façon sélective et irréversible l'ensemble des homo- et hétérodimères formés par les récepteurs de la famille ErbB. Les résultats de l'étude...
PUBLIÉ LE : 04 février 2015
PARU DANS : La Lettre du Cancérologue / N° 1 / janv. 2015
Depuis, on a appris à reconnaître leurs effets indésirables et constaté que certaines thérapies ciblées s'accompagnent d'une atteinte très fréquente des muqueuses. Cependant, celle-ci diffère de l'atteinte radio- et/ou...
PUBLIÉ LE : 27 mars 2014
PARU DANS : La Lettre du Cancérologue / N° 3 / mars 2014
Nous rapportons les conclusions du congrès MACC7 − 2es Journées de radiothérapie du pôle régional de cancérologie de Poitiers, réunion de consensus sur la prise en charge globale des cancers des voies aérodigestives supérieures...
PUBLIÉ LE : 14 décembre 2011
PARU DANS : La Lettre d'Oto-Rhino-Laryngologie / N° 327 / déc. 2011
Nous rapportons les conclusions du congrès MACC7 − 2es Journées de radiothérapie du pôle régional de cancérologie de Poitiers, réunion de consensus sur la prise en charge globale des cancers des voies aérodigestives supérieures...
PUBLIÉ LE : 13 décembre 2011
PARU DANS : La Lettre du Cancérologue / N° 10 / déc. 2011
Centre De Haute Energie, Nice
Radiotherapie
Position
Medical Doctor
January 2014 - present
Centre De Haute Energie, Nice
Radiation Oncology
France
Position
Head of Department
August 2008 - December 2013
Centre Hospitalier Universitaire de Poitiers
Department of Radiation Oncology
France
Position
Head of Department
Show All
Publications
Publications (348)
Management of oral and gastrointestinal mucositis: ESMO Clinical Recommendations
Article
Full-text available
Jun 2008
Article
Full-text available
Jun 2016
Purpose: There is a large body of evidence supporting the efficacy of low level laser therapy (LLLT), more recently termed photobiomodulation (PBM), for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms invo...
Article
Full-text available
Jun 2016
Purpose: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT), more recently termed photobiomodulation (PBM) for the management of oral mucositis (OM) in patients undergoing radiotherapy for head and neck cancer (HNC). Recent advances in PBM technology, together with a better understanding of mechanisms invol...
Article
Feb 2008
Radiation dermatitis occurs to some degree in most patients receiving radiotherapy, with or without chemotherapy. Patients with squamous cell carcinoma of the head and neck (SCCHN) who receive radiotherapy in combination with epidermal growth factor receptor (EGFR) inhibitors, such as cetuximab, may develop a characteristic acne-like rash in additi...
Article
Dec 1997
Article
Full-text available
Nov 2022
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 virus was first recognized in late 2019 and remains a significant threat. We therefore assessed the use of local methylene blue photodynamic viral inactivation (MB-PDI) in the oral and nasal cavities, in combination with the systemic anti-viral, anti-inflammatory and antioxidant actions of or...
AFSOS-SFRO-SFH-SFNEP-SFCE-GFRP guidelines on radio-induced nausea and vomiting
Article
Oct 2022
Introduction The prevalence of radiation-induced nausea and vomiting varies between 40 and 80%. They have many consequences on treatment and comorbidities. This work thus aimed to define clinical practice guidelines for the management of radiation-induced nausea and vomiting. Methods XXXXX, XXXX, XXX, XXXXX, XXXX and XXXX compiled a working group...
Article
Full-text available
Aug 2022
Disclaimer This article is based on recommendations from the 12 th WALT Congress, Nice, October 3-6, 2018, and a follow-up review of the existing data and the clinical observations of an international multidisciplinary panel of clinicians and researchers with expertise in the area of supportive care in cancer and/or PBM clinical application and dos...
Quality Assessment of PBM Protocols for Oral Complications in Head and Neck Cancer Patients: Part 1
Article
Full-text available
Jul 2022
Background Radiotherapy and chemotherapy are frequently employed in head and neck cancer (HNC) patients causing significant side effects that impair life quality and prognosis. Photobiomodulation (PBM) has become a growing approach to managing such oral complications. Despite its proven efficacy and absence of contraindications, there is still a la...
Implementation of Photobiomodulation for Radio or Chemo- Induced Mucositis
Article
Mar 2022
Aim: Photobiomodulation (PBM) therapy is used for the management of oral mucositis in patients treated with radiotherapy and/or chemotherapy. The aim of this study is to evaluate the efficacy and safety of PBM for oral mucositis during radiotherapy with or without chemotherapy. Materials and Methods: A total of 62 patients diagnosed with a mucositi...
Article
Full-text available
Mar 2022
Neuropathic pain (NP) can be challenging to treat effectively as analgesic pharmacotherapy (MED) can reduce pain, but the majority of patients do not experience complete pain relief. Our pilot approach is to assess the feasibility and efficacy of an evidence-based photobiomodulation (PBM) intervention protocol. This would be as an alternative to pa...
Article
Full-text available
Mar 2022
Abstract: Neuropathic pain (NP) can be challenging to treat effectively as analgesic pharmacotherapy (MED) can reduce pain, but the majority of patients do not experience complete pain relief. Our pilot approach is to assess the feasibility and efficacy of an evidence-based photobiomodulation (PBM) intervention protocol. This would be as an alterna...
Article
Full-text available
Feb 2022
Purpose The study aims to assess the feasibility, safety, and tolerability of CareMin650, a new photobiomodulation device, in patients treated by radiotherapy (RT) and to collect preliminary data on efficacy for prevention and treatment of oral mucositis (OM) and radiation dermatitis (RD).Methods Safe PBM is a French, multicentric, prospective, non...
Principles and Practice of Radiation Oncology and Modern Radiation Therapy Techniques
Chapter
Jan 2022
This chapter describes the basic principles involved in the science and practice of radiation biology and radiation oncology. It also briefly describes the role of medical physicists, radioprotection, and radiosensitization and common principles involved in treating a patient using radiation therapy (RT).
Radiotherapy of salivary gland tumours
Article
Dec 2021
Primary tumours of the salivary glands account for about 5 to 10% of tumours of the head and neck. These tumours represent a multitude of situations and histologies, where surgery is the mainstay of treatment and radiotherapy is frequently needed for malignant tumours (in case of stage T3–T4, nodal involvement, extraparotid invasion, positive or cl...
Article
Full-text available
Nov 2021
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). Photobiomodulation therapy (PBMT) has been utilised in npBMS management, however, its role of intervention remains controversial. The aim of this systematic review and meta-analysis of CRD 42020198921 PROSPERO reg...
Article
Full-text available
Nov 2021
Mitochondrial homeostasis is crucial for energy production and neuronal survival in neurological primary burning mouth syndrome (npBMS). Photobiomodulation therapy (PBMT) has been utilised in npBMS management, however, its role of intervention remains controversial. The aim of this systematic review and meta-analysis of CRD 42020198921 PROSPERO reg...
Conference Paper
Oct 2021
PHOTOBIOMODULATION IN ONCOLOGY: PREVENTIVE AND CURATIVE MANAGEMENT OF CANCER THERAPY-INDUCED TOXICITIES
Clinical use of photobiomodulation as a supportive care during radiation therapy
Article
Oct 2021
PBM in Radiation Oncology
The role of benzydamine in prevention and treatment of chemoradiotherapy-induced mucositis
Article
Full-text available
Oct 2021
Purpose To discuss the role of benzydamine in the prevention and treatment of radiation-induced oral mucositis (OM) in head and neck (H&N) cancer patients. This document represents an expert opinion paper on indications and key-role aspects in OM pathogenesis, prevention and treatment. Oral mucositis OM represents a common side effect of chemother...
Article
Oct 2021
Introduction et but de l’étude La photobiomodulation est recommandée pour prévenir la mucite orale au cours du cancer de la tête et du cou traité par irradiation et a montré des résultats encourageants sur la radiodermite au cours du cancer du sein. Les dispositifs actuels ne permettent pas une administration reproductible ni standardisée. CareMin6...
photobiomodulation-perspectives-in-the-treatment-of-genital-conseqences of cancer therapy
Article
Sep 2021
Article
Full-text available
Sep 2021
Photobiomodulation-based (PBM-based) therapies show promising results in mucositis and dermatitis treatment by stimulating wound healing mechanisms such as cell proliferation and migration. The aim of the present study is to investigate the in vitro effects of CareMin650 on the proliferation and migration of two different types of cells, namely can...
Direct costs associated with the management of mucositis: A systematic review
Article
Jul 2021
[...]
Mucositis is one of the more frequent and costly adverse events following cancer treatment. To evaluate and report the direct economic outcomes associated with the management of mucositis across several cancer treatments we conducted a systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) sta...
Article
Jul 2021
Purpose: To evaluate the current and potential indications of photobiomodulation (PBM) and their level of evidence in the prevention or management of radiation therapy-related side effects. Materials and methods: The Embase, Medline/PubMed, Cochrane, EBSCO, Scopus, and LILACS databases were systematically reviewed to include and analyze publicat...
Article
Full-text available
Jun 2021
This systematic review and meta-analysis (PROSPERO registration; ref CRD 42020198921) aimed to govern photobiomodulation therapy (PBMT) efficacy in temporomandibular disorder (TMD). PRISMA guidelines and Cochrane Collaboration recommendations were followed. Differences in pain reduction assessment by qualitative measurement with visual analogue sca...
Preprint
Full-text available
Jun 2021
Purpose To assess the feasibility, safety and tolerability of CareMin650, a new photobiomodulation device, in patients treated by radiotherapy (RT). To collect preliminary data on efficacy for prevention and treatment of oral mucositis (OM) and radiation dermatitis (RD). Methods French, multicentric, prospective, non-comparative study. Inclusion of...
Article
Jun 2021
Purpose: Endoscopic endonasal surgery (EES) is becoming a standard for most malignant sinonasal tumours. Margin analysis after piecemeal resection is complex and optimally relies on accurate histosurgical mapping. Postoperative radiotherapy may be adapted based on margin assessment mapping to reduce the dose to some sinonasal subvolumes. We assess...
Article
Full-text available
Apr 2021
Background Oral mucositis (OM) is a severe complication cancer patients undergo when treated with chemoradiotherapy. Photobiomodulation (PBM) therapy also known as low-level laser therapy has been increasingly used for the treatment of such oral toxicity. The aim of this review is to discuss the mechanisms of photobiomodulation (PBM) regarding OM p...
Article
Apr 2021
Background Randomised, controlled trials and meta-analyses have shown the survival benefit of concomitant chemoradiotherapy or hyperfractionated radiotherapy in the treatment of locally advanced head and neck cancer. However, the relative efficacy of these treatments is unknown. We aimed to determine whether one treatment was superior to the other....
Article
Mar 2021
BACKGROUND AND PURPOSE: The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. MATERIALS AND METHODS: Published or unpublished randomized trials including patients with non-...
Article
Jan 2021
Background and purpose The Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results. Materials and methods Published or unpublished randomized trials including patients with non-m...
Article
Nov 2020
Background To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients and methods Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Ne...
R E V I E W Safety and efficacy of photobiomodulation therapy in oncology: A systematic review
Article
Full-text available
Oct 2020
We performed a systematic review of the current literature addressing the safety and efficacy of photobiomodulation therapy (PBMT) in cancer patients. In this systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. In vitro, in vivo, and clinical studies, which investigated the effect...
Article
Aug 2020
BACKGROUND: Mucositis is a significant toxicity of cancer therapy with numerous systemic sequelae. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ ISOO) Clinical Practice Guidelines for the management of mucositis. METHODS: The literature...
Article
May 2020
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy (CT), affecting 68% of patients. Current treatment strategies are based on pharmacological symptom management, but have limited results. Photobiomodulation therapy (PBMT) is a new and emerging therapeutic tool in the supportive care of cancer patie...
Article
May 2020
Objective: A narrative review of the available scientific evidence to identify the current proposals relating the use of photobiomodulation (PBM) to treat acute radiodermatitis (ARD), to guide future research. Background data: A devastating side effect of radiotherapy (RT) is ARD, defined as an inflammatory skin reaction induced by RT. Currently,...
Photobiomodulation for Side Effects of Cancer Therapy
Article
May 2020
Article
Full-text available
May 2020
Objective: The severity of breakthrough cancer pain (BTcP) impacts patients' quality of life, increases the risk of anxiety and depression, lowers functional capacities, and may lead to poor compliance with cancer treatments. The aim of the current study was to assess, in a real-life setting, patient satisfaction with a fentanyl-pectin-nasal-spray...
Photobiomodulation Safety In Cancer Patients
Article
Mar 2020
The recently published paper written by S. Sonis, entitled "Could the impact of photobiomodulation on tumor response to radiation be affected by tumor heterogeneity?", is a new contribution to the active field of photobiomodulation (PBM) research which focuses upon in vitro and molecular measures. This commentary raises an important question regard...
Chapter
Jan 2020
Protocoles thérapeutiques des cancers parotidiens, submandibulaires
Chapter
Jan 2020
Article
Dec 2019
BACKGROUND:Head and neck mucosal melanoma (HNMM) is aggressive and rare, with a poor prognosis because of its high metastatic potential. The two main subtypes are sinonasal (sinonasal mucosal melanoma [SNMM]) and oral cavity (oral cavity mucosal melanoma [OCMM]). Consensual therapeutic guidelines considering the primary tumour site and tumour-node-...
Radiation induced optic neuropathy: Does treatment modality influence the risk?
Article
Nov 2019
Radiation induced optic neuropathy (RION) is a rare but disastrous complication of radiation therapy in treatment of periorbital tumors. The objective of this study is to investigate the incidence of RION in series of patients treated from peri orbital tumors by recent photon and proton irradiation modalities. We searched the Pub Med database for s...
Article
Full-text available
Oct 2019
Purpose To systematically review the literature and update the evidence-based clinical practice guidelines for the use of photobiomodulation (PBM), such as laser and other light therapies, for the prevention and/or treatment of oral mucositis (OM). Methods A systematic review was conducted by the Mucositis Study Group of the Multinational Associat...
Article
Oct 2019
Purpose: Oral mucositis (OM) is a frequent and painful sequelae of concomitant chemoradiation (CRT) used for the treatment of head and neck cancer (HNC) for which there is no effective intervention. This randomized, placebo-controlled study evaluated the efficacy of a novel, mucoadhesive topical tablet formulation of clonidine in mitigating CRT-in...
Radiotherapy mucositis in head and neck cancer: prevention by low-energy surface laser
Article
Sep 2019
Background Modern radiotherapy (RT) planning techniques and the use of oral supportive care have reduced the occurrence of acute radiation-induced toxicities. Oral mucositis remains a major concern in patients with head and neck cancer as it can compromise treatment compliance and outcome. Objective To report the rate of mucositis with the prevent...
Prevention of radiotherapy-induced mucositis using surface low energy laser in head and neck cancer
Article
Aug 2019
Oral Mucosal Injury Caused by Targeted Cancer Therapies
Article
Aug 2019
Targeted cancer therapies have fundamentally transformed the treatment of many types of cancers over the past decade, including breast, colorectal, lung, and pancreatic cancers, as well as lymphoma, leukemia, and multiple myeloma. The unique mechanisms of action of these agents have resulted in many patients experiencing enhanced tumor response tog...
Management of skin toxicities during panitumumab treatment in metastatic colorectal cancer
Article
Full-text available
Aug 2019
Background: Anti-epidermal growth factor receptor therapy is associated with skin adverse events not previously reported with conventional chemotherapy. Prophylactic actions are recommended, but routine clinical management of these toxicities and their impact on quality of life remain unknown. Aim: To assess the dermatological toxicities reporte...
Chapter
Full-text available
Jul 2019
Évolutions dans la prise en charge des métastases ganglionnaires cervicales sans cancer primitif retrouvé : doses et volumes cibles de la radiothérapie avec modulation d’intensité.
Article
Full-text available
May 2019
Background Low-level laser therapy (LLLT) also called Photobiomodulation therapy (PBMT) could reduce oral mucositis (OM) incidence and severity in head and neck cancer patients treated by chemoradiotherapy, however randomised data about efficacy and safety are missing with curative dose 4 J/cm². Methods This phase III trial was conducted in patien...
Article
Apr 2019
Uni or bilateral Irradiation in Cervical Lymph Node Metastases of Unknown Primary?
Article
Nov 2018
Irradiation uni- ou bilatérale des métastases ganglionnaires cervicales de cancer primitif inconnu ?
Article
Full-text available
Oct 2018
Objectif de l’étude Les adénopathies cervicales du carcinome primaire inconnu divisent la communauté médicale entre ceux qui favorisent l’irradiation élective unilatérale et ceux qui préconisent l’irradiation bilatérale du cou. Nous voulions évaluer les contrôles locaux et régionaux et la toxicité après irradiation cervicale bilatérale ou unilatéra...
Management of radiation-induced mucosal necrosis with photobiomodulation therapy.
Article
Full-text available
Jul 2018
Article
Full-text available
May 2018
This commentary attempts to clarify the setting of photobiomodulation (BPM) therapy in the management of oral mucositis. The suggested dose range balances efficacy data with our current understanding about PBM safety. The literature about the molecular basis of photobiomodulation and its controversial relationship to malignant transformation is bri...
Management of radiation-induced mucosal necrosis with photobiomodulation therapy
Article
Full-text available
May 2018
Article
Full-text available
May 2018
Purpose or review: There is a large body of evidence supporting the efficacy of low-level laser therapy (LLLT) also known as PhotoBioModulation (PBM) when used for the prevention and/or treatment of oral mucositis in patients undergoing radiotherapy for head and neck cancer, or high-dose chemotherapy regimens. This review aims at giving the state...
Douleurs liées aux mucites : episil®, pourquoi pas ? Le Flyer
Article
Full-text available
Apr 2018
EP-1138: Laser Therapy for radiochemotherapy-induced mucositis in HNC: a randomised, phase III trial
Article
Apr 2018
Article
Full-text available
Jan 2018
Purpose As many as 50% of patients with cancer develop acute skin reactions to some degree with radiotherapy. Proactive skin care is often recommended to minimise these skin reactions and maintain the integrity of the epidermal barrier; nevertheless, no consensual guidelines are systematically used. This multicentre, observational, prospective stud...
Prevention and treatment of acute and chronic radiodermatitis
Article
Full-text available
Nov 2017
Sophie Seité,1 René-Jean Bensadoun,2 Jean-Michel Mazer3 1La Roche-Posay Laboratoire Dermatologique, Levallois-Perret, 2Centre de Haute Energie (CHE), Nice, 3Centre Laser International de la Peau, Paris, France Abstract: More than half the number of patients with cancer, who are treated with radiotherapy, will have radiodermatitis at some point duri...
Article
Full-text available
Oct 2017
Objectif de l’étude La laserthérapie de basse énergie pourrait réduire l’incidence et la sévérité des mucites orales au cours des chimioradiothérapies en cancérologie ORL. L’efficacité de la laserthérapie de basse énergie a été évaluée dans cet essai contrôlé randomisé en triple aveugle. Matériel et méthode Cet essai de phase III concernait des pa...
Article
Full-text available
Oct 2017
Patients undergoing radiation therapy for the head and neck are susceptible to a significant and often abrupt deterioration in their oral health. The oral morbidities of radiation therapy include but are not limited to an increased susceptibility to dental caries and periodontal disease. They also include profound and often permanent functional and...
Mise en place de l’audit patient traceur au sein d’un centre privé de radiothérapie
Article
Sep 2017
The "tracer patient" audit is an evaluation method introduced by the French health authority in the V2014 certification. This is not mandatory in private radiotherapy centres. In our continuous quality improvement approach and in order to improve the management of patient care, the management of our radiation therapy centre has decided to use this...
Supportive Care Organization in France: a national in-depth survey among patients and oncologists
Article
Full-text available
Jul 2017
PurposeMedical doctors’ (MDs), but not patients’, perception of supportive care in cancer (SCC) in France has been previously assessed in a national survey. This study evaluated MDs and patients’ perceptions of the SCC organization and implementation in France. Methods The French SCC Association conducted two observational studies: study 1 (S1), co...
Article
May 2017
Article
Apr 2017
Introduction: Single nucleotide polymorphisms (SNPs) of DNA repair and apoptosis genes have been associated with outcome in head and neck squamous cell carcinoma (HNSCC) patients receiving radiotherapy (RT). Our goal was to conduct a candidate gene study in HNSCC patients receiving RT or chemoRT. Methods: 122 non-resectable HNSCC patients underg...
Article
Mar 2017
Article
Full-text available
Dec 2016
Necrosis of the oral mucosa following head and neck cancer radiation therapy presents considerable clinical management challenges. We report three cases of symptomatic persisting oral ulcerations where the addition of photobiomodulation therapy resulted in a rapid resolution of the oral lesions and in patient symptoms. These cases suggest that phot...
Chapter
Full-text available
Dec 2016
Free radicals are responsible for the effects and toxicities associated with irradiation. For this reason, head and neck cancer patients often use trace elements or vitamins to act as scavengers of free radicals in order to prevent the side effects that occur during and after the treatment phase. Amifostine is the only clinically approved free radi...
Article
Full-text available
Nov 2016
D ans cet article, nous traiterons, à partir du référentiel ESMO 2015 (1), des lésions de la muqueuse buccale et du tractus gastro-intestinal liées à l'administration de thérapies ciblées. Stomatite chez les patients bénéficiant d'une thérapie ciblée Ces dernières années, des lésions de la muqueuse buccale, souvent uniques et douloureuses, ont été...
Mitigation of Cancer Therapy Side-Effects with Light
Book
Full-text available
Oct 2016
'Light' from low level laser therapy, through a process called photobiomodulation (PBM), has been in existence in supportive care in cancer, in particular in the management of oral mucositis (OM) in patients undergoing chemotherapy, radiation therapy and haematopoietic stem cell transplantation. In this book the authors attempt to portray the curre...
Article
Full-text available
Sep 2016
Intensity-modulated radiation therapy (IMRT) is the gold standard for head and neck irradiation. It allows better protection to the organs at risk such as salivary glands and mandible, and can reduce the frequency of xerostomia, trismus and osteoradionecrosis. At the time of treatment planning, the mean dose to a single parotid gland should be kept...
A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells
Article
Full-text available
Aug 2016
Background Radioresistant glioblastoma stem cells (GSCs) contribute to tumor recurrence and identification of the molecular targets involved in radioresistance mechanisms is likely to enhance therapeutic efficacy. This study analyzed the DNA damage response following ionizing radiation (IR) in 10 GSC lines derived from patients. MethodsDNA damage w...
Article
Apr 2016
Proceedings Congres WALT NAALT 2014 (Arlington-Washington)
Data
Full-text available
Dec 2015
Article
Full-text available
Nov 2015
Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases
Article
Full-text available
Oct 2015
Objectives: To describe the clinical, histological and therapeutic characteristics of a prospective multicenter series of 95 head and neck adenoid cystic carcinoma patients, and to determine any prognostic factors for disease-free survival. Patients and methods: Ninety-five patients with adenoid cystic carcinoma were included in the Réseau d'Exp...
Article
Oct 2015
Objectifs Les rares études concernant la radiothérapie ORL des patients âgés de plus de 80 ans ont montré que le traitement était souvent moins agressif pour diminuer la toxicité au profit de la qualité de vie. Cette étude avait donc pour objectif d’étudier la faisabilité de la radiothérapie des cancers des voies aérodigestives supérieures chez les...
Low-Level Laser Therapy in the Management of Mucositis and Dermatitis Induced by Cancer Therapy
Article
Full-text available
Oct 2015
Article
Sep 2015
Résumé La prise en charge précoce des patients porteurs d’un cancer repose sur une coordination et des échanges de qualité entre les différents acteurs de soins. Ces recommandations s’appuient sur la littérature avec des niveaux de preuve scientifiques. Le délai de prise en charge du malade sera optimisé en organisant le bilan le plus rapidement po...
Article
Sep 2015
Les auteurs exposent les recommandations de la Société française d’oto-rhino-laryngologie et de chirurgie de la face et du cou (SFORL) concernant l’organisation du parcours de soins en cancérologie des voies aéro-digestives supérieures (VADS), et en particulier la réunion de concertation pluridisciplinaire. Ce chapitre de recommandation concerne le...
Article
Jul 2015
Early management in oncology is based on coordination and high-quality exchange between the various health-care partners. The present guidelines are based on a literature search with levels of evidence. Treatment waiting time can be optimized by performing assessment as early as possible (Expert opinion), to limit the interval (ideally, less than 4...
Article
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Jul 2015
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Jul 2015
Article
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Jun 2015
The authors present the guidelines of the French Otorhinolaryngology - Head and Neck Surgery Society (SFORL) for patient pathway organization in head and neck cancer, and in particular for multidisciplinary team meetings. The present article concerns the therapeutic decision-making process. A multidisciplinary work group was entrusted with a review...
Article
May 2015
Data
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Apr 2015
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Mar 2015
The standard treatment of locally advanced (stage II and III) squamous cell carcinoma of the anal canal consists of concurrent chemoradiotherapy (two cycles of 5-fluoro-uracil, mitomycin C, on a 28-day cycle), with a dose of 45Gy in 1.8Gy per fraction in the prophylactic planning target volume and additional 14 to 20Gy in the boost planning target...
Article
Full-text available
Mar 2015
The standard treatment of locally advanced (stage II and III) squamous cell carcinoma of the anal canal consists of concurrent chemoradiotherapy (two cycles of 5-fluoro-uracil, mitomycin C, on a 28-day cycle), with a dose of 45 Gy in 1.8 Gy per fraction in the prophylactic planning target volume and additional 14 to 20 Gy in the boost planning targ...
Article
Mar 2015
Le traitement de référence des carcinomes épidermoïdes du canal anal localement évolués (stades II et III) est la chimioradiothérapie exclusive. Celle-ci délivre une dose de 45 Gy à raison de cinq fractions de 1,8 Gy par semaine dans un volume pelvien, puis un complément de dose de 14 à 20 Gy dans la tumeur. La chimiothérapie concomitante la plus s...
Article
Full-text available
Jan 2015
Purpose: Dermatologic adverse events (dAEs) in cancer treatment are frequent with the use of targeted therapies. These dAEs have been shown to have significant impact on health-related quality of life (HRQoL). While standardized assessment tools have been developed for physicians to assess severity of dAEs, there is a discord between objective and...
Low-Level Laser Therapy in the Management of Mucositis and Dermatitis Induced by Cancer-Therapy
Chapter
Full-text available
Jan 2015
Article
Oct 2014
Objectif La disparition des fils d’iridium et la limitation des ressources humaines et matériels ont abouti à l’abandon de la curiethérapie de bas débit de dose et la mise en place d’une unité fonctionnelle de curiethérapie de haut débit de dose. Nous avons rétrospectivement étudié la mise en place d’une curiethérapie de haut débit de dose multifra...
Conference Paper
Full-text available
Oct 2014
P080 Cancer de la prostate localisé, à risque intermédiaire ou élevé, dont le traitement a été une radiothérapie externe et incluant une curiethérapie de haut débit de dose : expérience du pôle régional de cancérologie de Poitou-Charentes Objectif Évaluation du contrôle tumoral et de la toxicité d'une escalade de dose par curiethérapie de haut débi...
Article
Oct 2014
Article
Oct 2014
Article
Oct 2014
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Cited
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National and Kapodistrian University of Athens
Institut Multidisciplinaire d'Oncologie - Clinique de Genolier
Amsterdam University Medical Center
Brigham and Women's Hospital
The University of Tennessee Health Science Center
Cited By
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University of Johannesburg
Federal University of Pernambuco
University of Campinas
Hadassah Medical Center
Academisch Medisch Centrum Universiteit van Amsterdam
Projects
Projects (9)
Predictive factors in Head & Neck Cancer
Project
To find and to evaluate biological and clinical predictive factors (of response to cancer therapy) in H&N cancer patients.
Cancer-therapy side effects in Head & Neck Cancer patients
Project
To prevent and treat side effects of treatment in H&N cancer.
Oral Candidiasis in Head and Neck cancer patients
Project
Management of Oral Candidiasis in cancer patients.
Project
Prevention and management of denutrition in cancer patients
Skin Toxicity of cancer therapy
Project
Prevention and management of cancer treatments-related skin toxicity.
Orofacial neuropathic pain and photobiomodulation therapy (PBMT)
Project
Aiming to evaluate the effect long-term effect of the PBMTin reducing and sustaining neuropathic pain after completing the PBMT.
Radiotherapy in salivary gland cancer
Project
chemoradiation in head and neck carcinoma
Project
Mitigation of cancer therapy-side effects with Light
Project
Guidelines. Ebook. Position paper. PBM Parameters.